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The evidence for the efficacy of colchicine in patients with chronic gout is derived from the published literatureTwo randomized clinical trials assessed the efficacy of colchicine 0.6 mg twice a day for the prophylaxis of gout flares in patients with gout initiating treatment with urate lowering therapyIn both trialstreatment with colchicine decreased the frequency of gout flares.
These are not all of the possible side effects of colchicine capsulesFor more information ask your healthcare provider or pharmacist.
Pharmacokinetic studies evaluating changes in systemic levels of colchicine when co-administered with CYP3A4 inhibitors in healthy volunteers have been conducted with colchicine capsulesWhile voriconazole 200 mg BID for 5 daysconsidered a strong CYP3A4 inhibitorand cimetidine 800 mg BID for 5 daysconsidered a weak CYP3A4 inhibitordid not cause any changes in colchicine systemic levelsfluconazole 200 mg QD for 4 days with a 400 mg loading doseconsidered a moderate CYP3A4 inhibitorincreased colchicine AUC by 40As voriconazolecimetidineand fluconazole are known as CYP3A4 inhibitors that do not inhibit P-gpthese studies show that CYP3A4 inhibition by itself may not lead to clinically significant increases in colchicine systemic levels in humansand P-gp inhibition in addition to CYP3A4 inhibition may be necessary for clinically meaningful interactions of colchicineHoweverbased on published case reports that indicate the presence of colchicine toxicity when colchicine is co-administered with strong to moderate CYP3A4 inhibitors such as clarithromycinerythromycingrapefruit juiceetcas well as the 40increase in systemic levels of colchicine observed with concomitantly administered fluconazolea moderate CYP3A4 inhibitor that is not known to inhibit P-gpin a drug-drug interaction studythe drug-drug interaction potential of colchicine with strong or moderate CYP3A4 inhibitors that do not inhibit P-gp cannot be ruled out completely.
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your doctor then will most likely prescribe you either allopurinol, colchicine, phobenecid or nsaids to get rid of uric acid before it crystallizes and causes you a painful gout .