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Published on August 16, 2018 under Event Organizing

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The onset of diuresis following oral administration is within 1 hourThe peak effect occurs within the first or second hourThe duration of diuretic effect is 6 to 8 hours.

Whenever adverse reactions are moderate or severeLASIX dosage should be reduced or therapy withdrawn.

Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemiaassociated with nephrotic syndromeototoxicity is associated with rapid injectionsevere renal impairmentuse of higher than recommended dosesconcomitant therapy with aminoglycoside antibioticsethacrynic acidor other ototoxic drugs.

All patients receiving LASIX therapy should be observed for these signs or symptoms of fluid or electrolyte imbalancehyponatremiahypochloremic alkalosishypokalemiahypomagnesemia or hypocalcemiadryness of mouththirstweaknesslethargydrowsinessrestlessnessmuscle pains or crampsmuscular fatiguehypotensionoliguriatachycardiaarrhythmiaor gastrointestinal disturbances such as nausea and vomitingIncreases in blood glucose and alterations in glucose tolerance testswith abnormalities of the fasting and 2-hour postprandial sugarhave been observedand rarelyprecipitation of diabetes mellitus has been reported.

The usual initial dose of LASIX is 20 to 80 mg given as a single doseOrdinarily a prompt diuresis ensuesIf neededthe same dose can be administered 6 to 8 hours later or the dose may be increasedThe dose may be raised by 20 or 40 mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtainedThe individually determined single dose should then be given once or twice dailyegat 8 am and 2 pmThe dose of LASIX may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states.

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